In a previous study we were able to demonstrate that ZNF224 acts as a co-activator of WT1(−KTS) in the regulation of proapoptotic genes and suppresses WT1-mediated transactivation of antiapoptotic genes in the CML-derived cell line K562, thus pointing to a role for ZNF224/WT1(−KTS) interaction in leukemia. Here, ZNF224 is linked to chronic myelogenous leukemia, BCR-ABL1 positive.