These facts further confirmed that miR-146b-5p as a tumor suppressor inhibited cell proliferation and promoted apoptosis in malignant gliomas, and suggested that miR-146b-5p exerted the above effects at least partly by blocking TRAF6 expression, highlighting the potential values of miR-146b-5p and TRAF6 in the therapy of malignant gliomas. This evidence concerns the gene TRAF6 and malignant glioma.