TRAF6 and central nervous system cancer: Our present data demonstrated that miR-146b-5p expression was significantly decreased and TRAF6 expression was significantly increased with the grade elevation in 15 grade I glioma, 28 grade II glioma, 34 grade III glioma, and 70 glioblastoma (grade IV) specimens, suggesting that miR-146b-5p and TRAF6 were the potential biomarkers in distinguishing glioma grades.