The effects of CaM antagonists on TRA-8-induced apoptosis is not due to their toxicity or via stimulation of intrinsic apoptotic signaling pathways as seen in other cancer cells [31], as neither TFP nor TMX alone was found to affect the survival or apoptosis of the TRA-8 resistant pancreatic cancer cell lines. Here, TMX1 is linked to familial pancreatic carcinoma.