NEK2 and Ewing sarcoma: Aberrant NEK2 activity has been documented in multiple malignancies, including pediatric Ewing’s sarcoma, follicular lymphoma (FL), diffuse large B cell lymphoma (DLBCL), mammary gland tumor, leukemia, cervical, ovarian, breast cancers [10, 15, 16, 29–33].tumori Previous studies have shown that NEK2 contributes to assembly and maintenance of centrosomes and to bipolar spindle formation [12, 34, 35].