The main results of the present observational study can be summarized as follows: among patients with BAV, those treated with statins had smaller STJ at baseline and smaller AAo at baseline and at follow-up compared with patients non-treated with statins after correcting for age, presence of coronary artery disease and the use of angiotensin converting enzyme-inhibitors or angiotensin receptor blockers and beta-blockers. The gene discussed is ACE; the disease is coronary artery disorder.