Consequently, statins enhance the intracellular accumulation of ABCB1 substrates like doxorubicin, which augments cytotoxicity in neuroblastoma and rhabdomyosarcoma cells and may provide the classical argument for usage in an anti-cancer therapy (Tamplin et al. 1954; Werner et al. 2004, 2013; Demierre et al. 2005; Goard et al. 2010; Sieczkowski et al. 2010; Tanaka et al. 2010). This evidence concerns the gene ABCB1 and rhabdomyosarcoma.