TLR3 and chronic primary adrenal insufficiency: With respect to adrenal autoimmunity, TLR3-expressing adrenocortical carcinoma cells stimulated with poly(I:C) along with IFN-γ or tumor necrosis factor α display significant rise in production of CXCL10, a chemokine involved in autoimmune adrenal failure (Bratland et al. 2013).