In the absence of significant advantages in terms of OS, these new data regarding the response rate associated with the initial clinical evaluation of the patient may allow the construction of a treatment algorithm to guide the choice of a combination regimen in all RAS wild-type patients, with the addition of an anti-EGFR moAb in case of highly symptomatic patients who require a rapid reduction in tumor volume or, alternatively, of a regimen containing an anti-VEGF moAb, which also becomes the first choice of treatment in RAS mutated patients or carriers of a BRAF mutation [34]. This evidence concerns the gene EGFR and neoplasm.