Accordingly, knockdown of RFPL3 in H1299 cells with CBP overexpression repressed remarkably the elevated expression of hTERT protein (Figure 5B) and lung cancer cell viability (Figure 5C) mediated by increased CBP expression, suggesting again the coordination between RFPL3 and CBP in mediating hTERT transcription and expression and their further role in regulating lung cancer cell growth. This evidence concerns the gene CREBBP and lung cancer.