CREBBP and metastatic malignant neoplasm in the lymph nodes: Based on univariate analysis, the up-regulation of CBP and RFPL3 (P < 0.001), T3 stage (P = 0.045) and presence of lymph node metastasis (P= 0.016) were significant inferior prognostic factors for OS in patients with lung adenocarcinoma (Table 1B).