Multivariate analysis further indicated that the up-regulation of CBP and RFPL3 (P = 0.001) was independent prognostic predictors for OS in patients with lung adenocarcinoma enrolled in this study (Table 1B), suggesting that the important role of CBP and RFPL3 expression and their association with hTERT in predicting the prognosis of patients with lung cancers. The gene discussed is RFPL3; the disease is lung cancer.