We observed that the anti-tumor effect of STD is partially inhibited in CerS6 shRNA-silenced xenograft models (Fig. 7E; 77.2% and 75.2% inhibition of tumor growth in NC-shRNA-1 and NC-shRNA-3 xenograft models, respectively, vs. 23.5% and 18.0% inhibition of tumor growth by STD in CerS6-shRNA-1 and NC-shRNA-5 xenograft models, respectively). This evidence concerns the gene CERS6 and neoplasm.