PDCD1 and neoplasm: The interaction of PD-1 with LAG-3 was significantly reduced (30-40%) by treatment of the tumor and T cells with blocking antibodies anti-PD-L1 and anti-PD1, respectively (Figure 7C, lane 4), while treatment with anti-PD-L1 on tumor cells alone had a lesser effect (Figure 7C, lane 3).