We have previously demonstrated that a subset of tumor antigen-specific CD8+ T cells co-expressing LAG3 and PD1 are impaired in IFN-γ and TNF-α production and that simultaneous blockade of LAG3 and PD1 restores effector function of human ovarian tumor antigen-specific T cells to a level that is above the additive effects of single blockade of LAG3 or PD1 alone [10]. Here, PDCD1 is linked to neoplasm.