Consistent with the results of the tumor-bearing Lag3−/− and Pdcd1−/− OT-1 mice (Figure 1A), treating the C57BL/6 mice with single agent blockade did not have a clear benefit, however, combinatorial blockade with anti-LAG3 and anti-PD1 antibodies significantly delayed the growth of the IE9mp1 ovarian tumors (Figure 3A, p = 0.01). This evidence concerns the gene PDCD1 and neoplasm.