Our results demonstrate the following: (i) LAG3 and PD1 are elevated and co-expressed in TILs from murine ovarian tumor- and EG7-bearing mice and dual blockade of both molecules enhances antitumor immunity via enhanced CD8+ T effector frequency and function and reduced frequency of Treg cells in the tumor microenvironment. The gene discussed is LAG3; the disease is ovarian neoplasm.