The data (Figure 1B) showed that OT-1-Lag3−/−Pdcd1−/− tumor-bearing mice exhibited significantly improved survival compared with OT-1-WT or single knock out OT-1-Lag3−/− or OT-1-Pdcd1−/− mice (p = 0.0001, Log-rank test). This evidence concerns the gene LAG3 and neoplasm.