CCN2 and breast neoplasm: On the other hand, we found a significant CTGF DNA copy number gain in high-grade breast tumors in a 1,992-sample analysis (Supplementary Figure S3) [47], which might be the origin of elevated mRNA and protein expressions of CTGF, as no common mutation was detected in the CTGF promoter region in breast tumors in the COSMIC database (http://cancer.sanger.ac.uk/cancergenome/projects/cosmic/).