However, when we analyzed the datasets with separate stroma and tumor profiling [20, 21], we found that only high tumor-CTGF significantly correlated with shorter overall survival (p = 0.02) (Figure 1A), the patient survivals from high stroma-CTGF group and low stroma-CTGF group was no difference (p = 0.54) (Figure 1C). Here, CCN2 is linked to neoplasm.