Protein expressions of TNFR1 in the various cancer cell lines were in concord with the gene expressions of TNFR1 and tumor immunostaining of TNFR1 further confirmed that TNFR1 expressed higher in the over-CTGF-HMLER and HMLER-snail tumors than that in the control-HMLER and shCTGF2 tumors (Figure 7C–7E). The gene discussed is CCN2; the disease is cancer.