Nuclear hnRNPD overexpression in OSCCs and its emergence as a predictor of recurrence free survival in multivariate analysis in comparison with clinical and pathological parameters is an important novel finding in oral cancer, even though previous studies reported its overexpression in other malignancies including thyroid, melanoma, breast, cervix and murine lung tumors [4, 7, 16, 18, 48, 49, 35]. This evidence concerns the gene HNRNPD and lip and oral cavity carcinoma.