Of 183 OSCCs analyzed in this study, 65.6 % cases showed increased nuclear hnRNPD expression in tumor cells as compared to normal oral mucosa (p < 0.001, odds ratio (OR) = 8.1, 95 % CI = 4.6–14.5; Table 1 and Fig. 4d). This evidence concerns the gene HNRNPD and neoplasm.