CD47 and cancer: In conclusion, this study demonstrated a noninvasive photothermal therapy involving gold nanoshells and NIR laser irradiation; the therapy enables repeated intraperitoneal hyperthermia and can effectively kill cancer cells in vivo. The gold nanoshells conjugated with anti-CD47 antibodies are highly efficient in killing cancer cells, and reduce the required amount of gold nanoshells and duration of NIR irradiation.