Using a large cohort of stage I lung adenocarcinoma patients, we have identified forkhead box P3 (FoxP3)+/CD3+ lymphocytes infiltration index—which represents the ratio of regulatory T cells to total T cells—in tumor-related stroma, overexpression of tumoral interleukin-7 receptor (IL-7R), and loss of tumoral IL-12Rβ2 as independent prognostic factors [27]. The gene discussed is FOXP3; the disease is neoplasm.