The current National Comprehensive Cancer Network (NCCN) guidelines include anti-VEGF antibody therapy in addition to systemic FOLFOX (folinic acid/5-fluorouracil/oxaliplatin) and FOLFIRI (folinic acid/5-fluorouracil/irinotecan) chemotherapy for the treatment of unresectable/recurrent colorectal cancer [20]. The gene discussed is VEGFA; the disease is colorectal cancer.