Overexpression of AKT3 proteins decreased protein expression of TSC1 and TSC2 but increased protein abundance of phospho-AKT Ser473, phospho-AKT Thr308, and B-Raf in PC-3, DU-145, CA-HPV, and LNCaP PCa cells (Figure 8). Here, TSC1 is linked to posterior cortical atrophy.