INS and type 1 diabetes mellitus: On the other hand, Caixàs et al. observed that, after intensification of insulin treatment for the optimization of glycemic control in patients with T1D, VLDL particles, triglycerides, total LDL-C and HDL-C reached the levels of the control group, while the pattern of small LDL-C was also similar to that of the non-diabetic group, with no changes after optimization [37].