Rabasa-Lhoret et al. [4] showed that for continuous exercise at different intensities (25, 50, and 75% of maximal oxygen uptake (VO2max)), the risk of exercise-induced hypoglycemia could be minimized by an exercise intensity-dependent reduction of the short-acting premeal insulin administration (25, 50, and 100% of usual insulin dose) in subjects with T1DM. The gene discussed is INS; the disease is Hypoglycemia.