A recent study reported that CTCs are detected 2 times more effectively by ISET (isolation by size of epithelial tumor cells) than those by CellSearch, and that a subpopulation of CTCs, which did not express EpCAM (i.e., E-CTCs), can be detected in the blood of NSCLC patients [7]. The gene discussed is EPCAM; the disease is non-small cell lung carcinoma.