Finally, a higher sensitivity of PEA-15-deficient CD4+ T cells to Fas-dependent AICD [60] cannot be evoked to explain the lower frequency of CD4+ T cells reported in PEA-15-deficient mice; indeed, in accordance with Pastorino et al. [24], we showed that Fas-dependent AICD was preserved in PEA-15-deficient T cells, in contrast to the anti-apoptotic function of PEA-15 in fibroblasts, gliomas and astrocytes [23]. Here, CD4 is linked to central nervous system cancer.