Shi M et alfound a three-gene expression signature associated to early human hepatocellular carcinoma[29], constituted by the chemokine (C-X-C motif) receptor 2 (CXCR2), C–C chemokine receptor type 2 (CCR2) and the E1A-Binding Protein P400 (EP400). Here, CXCR2 is linked to hepatocellular carcinoma.