Consistent with those reports, we found the expression of CCL5 and CXCL10 in ESCC tissues was a) strongly elevated, compared to surrounding healthy tissues, and b) positively correlated with the local expression of CD8+ T lymphocyte markers, including CD8 and Granzyme B. These observations strongly indicate that CCL5 and CXCL10 are involved in the local recruitment of CD8+ T lymphocytes to ESCC lesions and their local retention. The gene discussed is CCL5; the disease is esophageal squamous cell carcinoma.