Transfection of HepG2 (Fig. 3A), SNU-449 (Fig. 3B) and SK-Hep-1 (Fig. 3C) cells with siSp1, siSp3, siSp4 and siHULC inhibited HCC cell proliferation and induced apoptosis (Annexin V staining) and the magnitude of these effects was cell context-dependent. Here, ANXA5 is linked to hepatocellular carcinoma.