Treatment for HCC is dependent on tumor stage and can include surgical resection, local ablation by radiofrequency treatment, transarterial chemobolization and radioembolization (TACE) [2] and the mechanism-based receptor tyrosine kinase (RTK) inhibitor sorafenib is also effective for treating patients with advanced HCC [4]. Here, NTRK1 is linked to hepatocellular carcinoma.