CDH2 and neoplasm: CDH1 levels decreased while CDH2 levels increased in siIGFBP2/CDDP-treated Flo-1 cells as compared to mock-treated or siNon-targeting controls (Supplementary Figure S5C), indicating an “E-cadherin to N-cadherin switch” that has been previously shown to contribute to tumor cell motility and invasion [41, 42].