The glycation products formed have the potential to bind the macrophages through the macrophage scavenger receptor and, to RAGEs and thus contribute in cancer development through their pro-inflammatory capabilities and by exploiting the requirement for the activation of interleukin 6 (IL-6)–mediated mitochondrial signal transducers and activators of transcription 3 (STAT3) [9–11]. The gene discussed is IL6; the disease is cancer.