PKM and colorectal cancer: Consistent with the target molecules inhibited in NDRG2-overexpressing colorectal cancer cells, the expression of GLUT1, glycolytic pathway-related enzymes HK2, PKM2 and LDHA increased significantly in NDRG2-knockdown Caco-2, HT-29 and HCT116 cells (Figure 2E and Supplementary Figure S3D).