NDRG2 inhibited glucose transporter 1, and three key regulatory enzymes HK2, PKM2 and LDHA in glycolysis, NDRG2 also inhibited glutamine transporter ASCT2 and glutaminase GLS1 in glutaminolysis, along with the inhibition of c-Myc in cancer cells. The gene discussed is SLC1A5; the disease is cancer.