By inhibiting the cleavage of EpCAM, EpAb2-6 prohibits tumor growth by preventing the translocation of EpICD into the nucleus (Fig. 2F), thus preventing the binding of EpICD to a multiprotein complex consisting of FHL2, β-catenin, and Lef-1, and thereby blocking both the down-regulation of p53 and p21, and the activation of EMT and iPS genes. The gene discussed is LEF1; the disease is neoplasm.