In this study, EpAb2-6 was observed to directly induce apoptosis in HCT116 and HCT116 (TP53−/−) cell lines in vitro (Fig. 2) and inhibit CRC tumor growth (Fig. 5 and Supplementary Fig. S3) and metastasis (Fig. 6) in vivo. This evidence concerns the gene TP53 and neoplasm.