CCL2 and neoplasm: We recently demonstrated that pharmacological blockade of A2B receptor significantly reduces tumor accumulation of MDSCs and decreases the levels of inflammatory mediators, such as IL-10 and monocyte chemoattractant protein (MCP)-1 (also known as C-C motif ligand-2, CCL-2) [22, 23], that can drive the recruitment of MDSCs into tumor tissue [24, 25].