Furthermore, some studies show that the Bmi-1 gene is also related in self-renewal and differentiation of normal and tumor stem cells [16, 17], prevents senescence and immortalizes cells by activating telomerase [18], hematopoiesis [19], neural and skeletal development [19], cell cycle [20], and protection against oxidative stress and DNA damage [21]. The gene discussed is BMI1; the disease is neoplasm.