We now report that SALL4 expression occurs in ICC, and that association between SALL4 expression and the expression of Ki67, CA199, AFP, GGT, and P53 in ICC cases evaluated by immunohistochemical staining, and that the relationship between SALL4 expression and overall survival of patients in ICC. The gene discussed is MKI67; the disease is intrahepatic cholangiocarcinoma.