Although a previous study showed that SALL4 expression status was not associated with the HCC tumor-node-metastasis and Barcelona Clinic Liver Cancer stages in either the Singapore cohort or the Hong Kong cohort [13], SALL4 was also reported to regulate cell proliferation through regulating the cyclin D1 and cyclin D2 expressions and promote the expression of genes involved in EMT that occurs in invasion and metastasis of cancer cells [9]. The gene discussed is CCND2; the disease is hepatocellular carcinoma.