YAP1 and cancer: Gene set enriched analysis (GSEA) conducted by a specialized bioinformatician (B.L), demonstrated that many genes involving oncogenic processes (EGFR, AKT1/2/3 and PI3K/mTOR) and cancer stemness signaling are down-regulated such as β-catenin in Wnt signaling and YAP-1 in Hippo signaling in addition of down-regulation of BCL-2, the major target of ABT-263 (Figure 4A).