As in HMCLs, cytotoxicity (Figure 8A) and apoptosis (Figure 8B, 8C) are increased when BIRD-2 and ABT-199 are combined, providing evidence that BIRD-2 functions together with BH3 mimetic agents in other Bcl-2-positive malignancies in addition to MM. This evidence concerns the gene BCL2 and Miyoshi myopathy.