Analysis of the relation of MTOR rs1064261 and AKT rs1130233 with clinicopathological parameters in GC patients suggested that the AKT rs1130233 GA and (GA+AA) variant genotypes occur more frequently in GC patients without lymph node metastasis than in those with lymph node metastasis (GA 89.1% vs. 71.1%, P = 0.012; GA+AA 92.2% vs. 81.1%, P = 0.030). The gene discussed is AKT1; the disease is metastatic malignant neoplasm in the lymph nodes.