Blast cells were treated with 10μM imatinib, 500μM ribavirin, and combination for 48h, and the results suggested that ribavirin alone significantly reduced the phosphorylation of mTOR/eIF4E, ERK/Mnk1/eIF4E signaling pathways, substrates Mcl-1, and p-Lyn in all 6 cases of Ph+ ALL primary blasts, and the combination of ribavirin and imatinib had greater effect on the signaling pathways, as described in the cell lines (Fig 6B and 6C). Here, MKNK1 is linked to acute lymphoblastic leukemia.