In summary, our studies demonstrated that ribavirin down-regulated the phosphorylation level of mTOR/eIF4E and ERK/Mnk1/eIF4E signaling pathways, inhibited the assembly of eIF4F translation initiation complexes, and reduced translation of onco-protein Mcl-1; therefore, it inhibited the proliferation of Ph+ ALL, CML cell lines and primary Ph+ acute lymphoblastic leukemic blasts. Here, MKNK1 is linked to acute lymphoblastic leukemia.