The results showed that ribavirin combined with imatinib had obvious synergistic anti-leukemic effect in Ph+ ALL by suppressing the phosphorylation of mTOR/eIF4E signaling pathway and, surprisingly, by inhibiting the ERK/Mnk1/eIF4E signaling pathway, blocking the assembly of eIF4F complexes, and inducing apoptosis. Here, MKNK1 is linked to acute lymphoblastic leukemia.