The parameters that distinguished MS patients from patients with other neurological disorders were the high intrathecal IgG synthesis, as depicted in the CSF/serum quotient diagrams for IgG (Reibergrams) that show disease-related IgG patterns with reference to albumin [21], the high IgG index and the correlation of the IgG index with CSF IL-4 levels. This evidence concerns the gene ALB and nervous system disorder.