Mutations in the 14-3-3 protein binding region of CaSR, including R896H and R898Q, have been identified in patients with pancreatitis [20] and idiopathic epilepsy syndrome [21], and a large in-frame deletion at the carboxyl terminus which eliminates the 14-3-3 binding site causes autosomal dominant hypocalcemia [22,23]. Here, CASR is linked to autosomal dominant hypocalcemia.