Taken together, we speculate that the combination of the rare homozygous alleles for rs5996080 and rs7973914, or the causative variants in LD with them, might simultaneously compromise the BAFFR and TNFR1/TNFR3 receptors’ function (Figure 3) and breast cancer survival by perturbing both the canonical and the non-canonical NF-κB pathways or their dynamics. Here, TNFRSF1A is linked to breast cancer.