It is of highly significance that our algorithm predicts that the amplification of CCNE1 gene conveys the identical information as to the mutation or deletion of RB1. As shown in Fig 4B, the protein encoded by CCNE1 inhibits that of RB1 (Fig 4B); both amplification of CCNE1 and mutation/deletion of RB1 have the same effect on a common signal, leading to aberrant regulation of cell cycle entry and thereby causing cancers. Here, CCNE1 is linked to cancer.