CHEK1 and cancer: Another example of a cancer-related RM, annotated with the GO term GO:0010564 (Regulation of Cell Cycle Process), includes 10 genes (BIRC5, CCNB2, CDC7, CDKN2A, CENPE, CENPF, CHEK1, NEK2, TIMELESS, UBE2C) that are up-regulated in 140 tumors.