It has been concluded that these prion-like domains may be primary-aggregating species, but the fact that these ALS-associated proteins are pulled into polyQ aggregates suggests that in some long-lived cells, such as neurons, there could be underlying protein quality control problems with proteins like FUS and TDP-43 getting preferentially recruited into pre-existing primary aggregates [93]. The gene discussed is TARDBP; the disease is amyotrophic lateral sclerosis.