In line with the current finding that inhibiting TRPC4/C5 with M084 suppresses depression-like and anxiety-like behaviors in mice, stimulation of the CCK-B receptor produced anxiogenic-like and depressant-like effects while blockade of the CCK action promoted antidepressant-like and anxiolytic-like effects [42]. This evidence concerns the gene TRPC4 and depressive symptom measurement.