Due to this limitation, and the effector memory phenotype of Vβ4+ CD8+ T cells [20], we were unable to efficiently deplete the Vβ4+ CD8+ T cells that accumulate during infection (Fig 9B)—although it should be noted that since overall CD8 levels at later times post-infection only recovered to < 50% of isotype control antibody treated mice, that there was an ca. 50% reduction in Vβ4+ CD8+ T cells. The gene discussed is CD8A; the disease is infection.