Our analysis of transcription levels of all three CCS genes (CAPN1, CAPN2 and CAST) had demonstrated that only the activity of CAPN1 (μ-calpain) gene was significantly, on average more than twice, higher in the blasts than in the control B cells; we have demonstrated earlier that this was the case for B-CLL cells[10]. The gene discussed is CAPN1; the disease is B-cell chronic lymphocytic leukemia.