One can speculate that decreased transcriptional activity of the CAST gene may result in relatively lower amounts of calpastatin (which we had observed at least in some blast samples) and, possibly, slower replacement of the inhibitor being used up by calpain activity (as we demonstrate in the Figs 3 and 5, respectively), thus strongly participating in the shifting of the stoichiometric balance within the CCS in ALL blasts towards relatively uncontrolled proteolysis by “unchecked” calpains. The gene discussed is CAST; the disease is acute lymphoblastic leukemia.