We found a statistically significant relationship between both PAGE4 (X1) and lymph node involvement (N1: X2, N2: X3) with CLM (P < 0.05) (Table 6) and therefore they were included in the multiple logistic regression model for liver metastasis risk prediction. PAGE4 and lymph node involvement were identified as independent risk factors for CLM (P < 0.05). This evidence concerns the gene PAGE4 and digestive system neoplasm.