Patel and coworkers [78], during investigation of hyperglycemia-induced functional changes: superoxide, hydrogen peroxide production, mitochondrial membrane polarization, and gene expression fingerprints of related enzymes in endothelial cells, have reported that hyperglycemia increased hydrogen peroxide production, hyperpolarized mitochondrial membrane, and downregulated CAT gene expression. This evidence concerns the gene CAT and Hyperglycemia.