A lot of work has been carried out by Chen et al. who demonstrated that a glycosylphosphatidylinositol- (GPI-) anchored epithelial extracellular membrane serine protease, prostasin/PRSS8, modulates EGFR signalling via enhancement of matriptase cleavage of the EGFR extracellular domain (ECD) and regulates SLUG and E-cadherin expression in cancer cells [41, 42]. The gene discussed is PRSS8; the disease is cancer.