We predict that the hippocampal-specific increases in SAP97, PSD-95 and GluN1 are likely related to the nonmotor symptoms of HD such as cognitive decline or dementia [38, 46, 47], while the striatal-specific decreases in PSD-95 and GluA2 are related to striatal degeneration and behavioural motor symptoms. The gene discussed is GRIN1; the disease is dementia.