In contrary to what is observed for FasL, ALS mutations do not lead to an increased sensitivity of motoneurons to LIGHT and/or IFNγ, but it is instead the aberrant secretion of IFNγ by mutant astrocytes and possibly other cell types that links the LIGHT/LT-βR pathway to motoneuron degeneration in this disease. This evidence concerns the gene LTBR and amyotrophic lateral sclerosis.