Even though LT-βR and HVEM lack an actual death domain, LIGHT was shown to induce moderate apoptosis of numerous tumor cell lines with a characteristically slow kinetic upon activation of LT-βR. Interestingly, this death-inducing property of LIGHT/LT-βR interaction depends on the presence of IFNγ [65–68]. The gene discussed is LTBR; the disease is neoplasm.