The concentrations of CSF-t-tau and CSF-p-tau were significantly higher in AD (t-tau; 378.0 ± 41.76 pg/mL; P < 0.001, p-tau; 42.4 ± 6.78 pg/mL; P < 0.028) than in the other groups. The gene discussed is MAPT; the disease is Alzheimer disease.