APP and Alzheimer disease: The double transgenic mouse expressing APPswe and mutated presenilin 1 (A246E) show enhanced theta rhythm during wakefulness and REM sleep [49], an observation that was reproduced, for the theta rhythm during REM sleep, by the same group in other AD transgenic mice that expressed the APP containing the Swedish and London mutations (V717I), the mutated presenilin 1 (A246E), as well as the TAU protein double mutant P301L and R406W, called the PLB1triple transgenic mouse [14].